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This comprehensive biography worksheet offers students an engaging exploration of Leonardo da Vinci’s extraordinary life and legacy. Designed for art history and general education classes, the worksheet guides learners through key moments in da Vinci’s career—from his early years in Vinci, Italy, to his masterworks such as The Last Supper and Mona Lisa. Students will examine da Vinci’s multifaceted talents as a painter, inventor, scientist, and thinker during the Italian Renaissance. With a blend of biographical questions, critical thinking prompts, and vocabulary development, this worksheet encourages deeper understanding of da Vinci’s influence on art and science, as well as the cultural context of the Renaissance period. Keywords: Leonardo da Vinci, Mona Lisa, The Last Supper, Vitruvian Man, Renaissance, Italian Renaissance, polymath, painter, inventor, scientist, anatomy, engineering, sfumato, chiaroscuro, fresco, drawing, Leonardo’s notebooks, art history, Florence, Milan, High Renaissance, art biography, Renaissance art, humanism, perspective, portrait, Leonardo da Vinci inventions, Renaissance master, Tuscan artist, Renaissance genius, art innovation, Renaissance thinker, Renaissance culture, master artist, Renaissance workshops, Renaissance sketches, Italian master